Thanks @antoniosarco - this is basically the information that is detailed in the JCuda FAQ . Fortunately, this now is mainly relevant for those who manually download the DLLs and JARs to set everything up locally. Starting with JCuda 0.8.0, the native libraries are contained in JAR (Maven Artifacts) and loaded from there. Since then, the number of bug reports related to UnsatisfiedLinkError have greatly decreased 